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Biologie: 5 Jobs in Ubstadt-Weiher

Berufsfeld
  • Biologie
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Biologie

PhD Project in Spatial Transcriptomics

Do. 19.05.2022
Heidelberg
The German Cancer Re­search Center is the largest bio­medi­cal re­search insti­tu­tion in Germany. With more than 3,000 employees, we operate an exten­sive scien­tific program in the field of cancer research.The laboratory of Dr. Moritz Gerstung (Division of Artificial Intelligence in Oncoclogy) at the German Cancer Research Center is looking for a PhD candidate for a project in spatial genomics. The group studies cancer evolution using a combination of AI analysis and new experimental technologies [1,2]. We have recently co-developed experimental protocols to detect mutations in tissue sections which map how cancers have grown in their tissue context [3]. This method, termed base specific in situ sequencing (BaSISS) extends the Cartana/10x ISS protocol. The BaSISS protocol combines sequencing of a tumour to identify mutations and localises these variants in a tumour section with single molecule padlock probes, which are interrogated by cyclic fluorescence microscopy. This generates signals from 100,000s of cells in a tissue, which are assembled into maps of subclonal growth. The protocols also allow for measuring the histopathological and transcriptomic changes acquired during tumour progression.The Division of Artificial Intelligence in Oncology is offering a PhD Project in Spatial Transcriptomics.(Ref-No. 2022-0152)We are looking for an experimentally skilled PhD candidate to apply these spatial genomics technologies to study the evolution of sarcomas and other cancer types. You will work alongside other lab members and in collaboration with the Single-cell Open Lab [4] to pursue our efforts to use spatial genomics for studying cancer evolution in our new lab at DKFZ [5] which opened in September 2021. Being part of an international interdisciplinary team working both experimentally and computationally will offer you a comprehensive training and opportunities to broaden your horizon in many ways. Furthermore, you will have the opportunity to take full advantage of all the training and social activities the DKFZ International PhD Program has to offer [6].Your responsibilities:Implementation and application of BaSISS and general ISS experimentsRun 10x visium spatial transcriptomics arrays on fresh and fixed tissuesAnalysis of the resulting data sets to map clonal evolution in tissues Integrate single-cell RNA sequencing data to understand clone-specific expression changes and interactions of cancer and normal cellsFurther information:Fu, Y. et al. Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis. Nature Cancer 1, 800–810 (2020)Gerstung, M. et al. The evolutionary history of 2,658 cancers. Nature 578, 122–128 (2020)Lomakin, A. et al. Spatial genomics maps the structure, character and evolution of cancer clones. bioRxiv (2021) doi:10.1101/2021.04.16.439912https://www.dkfz.de/en/single-cell-sequencing/open-lab.htmlhttps://www.dkfz.de/en/kuenstliche-intelligenz-in-der-onkologie/index.phphttps://www.dkfz.de/en/phd-programKey skills: An MSc in biological sciences or related field Experience with tissue preservation (e.g. fixation, cryo-preservation) and sectioning including both paraffin embedded and frozen tissue material Experience in fluorescence microscopy of cells or tissues Excellent communication skills in English and the ability to work effectively within a team  Desirable skills: Experience with immunohistochemistry and in situ hybridization Knowledge of image data pre-processing Ability to test, implement and troubleshoot new techniques and protocols Attention to detail and record keeping for sample and experimental tracking Interesting, versatile workplaceInternational, attractive working environmentCampus with modern state-of-the-art infrastructureAccess to international research networksDoctoral student payment including social benefitsFlexible working hoursComprehensive training and mentoring program through the Helmholtz International Graduate School
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Postdoc in Spatial Genomics

Do. 19.05.2022
Heidelberg
The German Cancer Re­search Center is the largest bio­medi­cal re­search insti­tu­tion in Germany. With more than 3,000 employees, we operate an exten­sive scien­tific program in the field of cancer research.The laboratory of Dr. Moritz Gerstung (Division of Artificial Intelligence in Oncoclogy) at the German Cancer Research Center (DKFZ) is looking for a postdoctoral fellow in spatial genomics. The group studies cancer evolution using a combination of AI analysis and new experimental technologies [1,2]. We have recently co-developed experimental protocols to detect mutations in tissue sections which map how cancers have grown in their tissue context [3]. This method, termed base specific in situ sequencing (BaSISS) extends the Cartana/10x ISS protocol. The BaSISS protocol combines sequencing of a tumour to identify mutations and localises these variants in a tumour section with single molecule padlock probes, which are interrogated by cyclic fluorescence microscopy. Our newly developed spot detection algorithm [4] then extracts signals from 100,000s of cells in a tissue, which are assembled into maps of subclonal growth. The protocols also allow for measuring the histopathological and transcriptomic changes acquired during tumour progression.The Division of Artificial Intelligence in Oncology is seeking a Postdoc in Spatial Genomics.(Ref-No. 2022-0153)We are looking for an experimental postdoc to apply these spatial genomics technologies to study the evolution of sarcomas and other cancer types. You will work alongside other lab members and in collaboration with the Single-cell Open Lab [5] to pursue our efforts to use spatial genomics for studying cancer evolution in our new lab at DKFZ [6] which opened in September 2021. Being part of an international interdisciplinary team working both experimentally and computationally will offer you a comprehensive training and opportunities to broaden your horizon in many ways. Furthermore, you will have the opportunity to take full advantage of all the training and social activities the DKFZ International Postdoc Program has to offer [7]. The starting date is flexible, depending on candidate preferences. Your responsibilities: Implement and run BaSISS and general ISS experiments Run 10x visium spatial transcriptomics arrays on fresh and fixed tissues Implement other standard in situ hybridisation assays (e.g. RNAscope, Nanostring GeoMx) widely utilized in the field Further information: Fu, Y. et al. Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis. Nature Cancer 1, 800–810 (2020) Gerstung, M. et al. The evolutionary history of 2,658 cancers. Nature 578, 122–128 (2020) Lomakin, A. et al. Spatial genomics maps the structure, character and evolution of cancer clones. bioRxiv (2021) doi:10.1101/2021.04.16.439912 Gataric, M. et al. PoSTcode: Probabilistic image-based spatial transcriptomics decoder. bioRxiv (2021) doi:10.1101/2021.10.12.464086 dkfz.de/en/single-cell-sequencing/open-lab dkfz.de/en/kuenstliche-intelligenz-in-der-onkologie/index dkfz.de/en/postdoc-program/index Key skills: A PhD in biological sciences or related field, with a focus on histology Advanced experience with tissue preservation (e.g. fixation, cryo-preservation) and sectioning including both paraffin embedded and frozen tissue material Experience in fluorescence microscopy of cells or tissues A proven track record of delivering ambitious biomedical research projects Excellent communication skills in English and the ability to work effectively within a team Desirable skills: Experience with immunohistochemistry and in situ hybridization Knowledge of image data pre-processing Ability to test, implement and troubleshoot new techniques and protocols Attention to detail and record keeping for sample and experimental tracking Interesting, versatile workplaceInternational, attractive working environmentCampus with modern state-of-the-art infrastructureSalary according to TV-L including social benefitsPossibility to work part-timeFlexible working hoursComprehensive further training programAccess to the DKFZ  International Postdoc Program
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Akademische Leitung Mikrobiologie und Hygienelabor (m/w/d)

Mi. 11.05.2022
Karlsruhe (Baden)
Der LADR Laborverbund Dr. Kramer & Kollegen ist ärztlich und inhabergeführt und besteht seit über 75 Jahren. An 18 Standorten sind bundesweit über 3.400 Mitarbeiter*innen tätig, um täglich über 20.000 niedergelassene Ärzt*innen und ca. 370 Kliniken mit dem kompletten Angebot moderner Labordiagnostik zu versorgen. Für unser LADR Laborzentrum in Baden-Baden suchen wir für die Abteilung Mikrobiologie und Hygienelabor eine*n (m/w/d) Akademische Leitung in Vollzeit. Akademische Leitung der Abteilung Mikrobiologie in Abstimmung mit der ärztlichen und technischen Leitung des Fachbereichs Methodische und organisatorische Weiterentwicklung der Abteilung Übergeordnete Verantwortung für Personal und abteilungsspezifisches Qualitätsmanagement Vorbereitung der Befunderstellung und ggf. telefonische Beratung der Einsender Qualifikation als Fachmikrobiolog*in oder vergleichbare Erfahrung in der mikrobiologischen Diagnostik Führungserfahrung ist wünschenswert, aber keine Bedingung Ggf. Erfahrung in molekularbiologischer Diagnostik / NAT Teamfähigkeit, Zuverlässigkeit und ein hohes Maß an Verantwortungsbewusstsein Wir bieten Ihnen einen sicheren Arbeitsplatz und spannende Aufgaben in einem modernen Arbeitsumfeld. Wir legen Wert auf die individuelle Förderung zur fachlichen und persönlichen Weiterentwicklung und gewähren alle sozialen Leistungen eines fortschrittlichen Unternehmens. Dazu zählen vor allem betriebliche Altersvorsorge inklusive AG-Zuschuss, betriebliches Gesundheitsmanagement, Einkaufsvorteile für Mitarbeiter*innen, JobRad und vieles mehr.
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Regulatory Affairs Manager Biocontrol Solutions (m/f/d)

Mo. 09.05.2022
Heidelberg
We are a team of experienced regulatory experts who can draw on many years of successful regulatory and scientific support in the authorisation of innovative biological and conventional plant protection products and biocides. Our clients are internationally distributed, comprise small to multi-national companies. Our team is located over Europe with partners in other parts of the world. We make use of state-of-the art communication techniques to facilitate a close cooperation with our clients and partners. Vali was founded in 2018 as a 100% subsidiary of ibacon GmbH, a scientific research company passionate since 1994 in providing the plant protection industry with GLP-compliant studies in the environmental risk assessment context. Over all these years the company gained substantial confidence as a reliable partner supporting industry on the way to the market authorization of their products. We founded Vali to go a step further and to allocate regulatory services in a new environment stimulating a creative and dedicated development. Vali gives to our customers the desk support they ask us for to master increasingly complex and laborious regulatory requirements. To complement our regulatory scientific team, we are offering a position as Regulatory Affairs Manager Biocontrol Solutions (m/f/d) (part- or full-time/40 h)  Project coordination and management of applications according to the EU regulatory framework EC Regulation 1107/2009 (approval or renewal of microbial pest control agents and plant protection products) Regulatory and strategical advice to facilitate the evaluation and registration of biocontrol products Regular communications with clients, contract research organisations and authorities Support the preparation of registration dossiers for biological plant protection products Preparation and coordination of data gap analysis Literature searches and reviews Support the development of sustainable biocontrol solutions as part of the KISAR group Occasional support to our Business Development team You will be working in a team of experts from different scientific disciplines together with a lead project manager  A university degree in biology, agricultural science or a related discipline with focus on microbiology Professional experience in regulatory affairs and in the evaluation of biological plant protection products  Experience in the evaluation of biological properties of microbial pest control agents High level of self-motivation and good time management skills Capability to work independently in your discipline while contributing to the success of your interdisciplinary team Excellent written and verbal communication skills in English, further language skills in a second European language would be an asset Profound skills in standard MS Office applications  Friendly working environment, with career opportunities in a growing team Flexible working hours and part time models Attractive salary added by performance-based bonuses Support of your private pension plan Coffee, tea and water are offered for free The location of your team will be Weinheim, Germany, near Heidelberg, with home office as an option.
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Regulatory Scientific Expert in Efficacy of Biocides (m/f/d)

Mo. 09.05.2022
Heidelberg
We are a team of experienced regulatory experts who can draw on many years of successful regulatory and scientific support in the authorisation of innovative biological and conventional plant protection products and biocides. Our clients are internationally distributed, comprise small to multi-national companies. Our team is located over Europe with partners in other parts of the world. We make use of state-of-the art communication techniques to facilitate a close cooperation with our clients and partners. Vali was founded in 2018 as a 100% subsidiary of ibacon GmbH, a scientific research company passionate since 1994 in providing the plant protection industry with GLP-compliant studies in the environmental risk assessment context. Over all these years the company gained substantial confidence as a reliable partner supporting industry on the way to the market authorization of their products. We founded Vali to go a step further and to allocate regulatory services in a new environment stimulating a creative and dedicated development. Vali gives to our customers the desk support they ask us for to master increasingly complex and laborious regulatory requirements. To complement our regulatory scientific team, we are offering a position as Regulatory Scientific Expert in Efficacy of Biocides (m/f/d) (part- or full-time/40 h) Preparation of registration dossiers for biocides for all product types Evaluation of data packages for biocides Data gap analysis and proposals for the conduct of further trials Development of testing strategies and monitoring of studies Regular communications with clients, contract research organisations and authorities You will be working in a team of experts from different scientific disciplines together with a lead project manager, supported by the documentation group. A degree in (bio-)chemistry, biotechnology, biology or a related discipline, a focus on microbiology would be an asset  Regulatory experience in the evaluation of efficacy of biocides High level of self-motivation and good time management skills Capability to work independently in your discipline while contributing to the success of your interdisciplinary team Excellent written and verbal communication skills in English, further language skills would be an asset Profound skills in standard MS Office applications, IUCLID skills would be an asset Friendly working environment, with career opportunities in a growing team  Flexible working hours and part time models Attractive salary added by performance-based bonuses Support of your private pension plan Coffee, tea and water are offered for free The location of your team will be Weinheim, Germany, near Heidelberg, with home office as an option.
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